Combined effects of PEGylation and particle size on uptake of PLGA particles by macrophage cells
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Abstract:
Objective:At the present study, relationship between phagocytosis of PLGA particles and combined effects of particle size and surface PEGylation was investigated. Materials and Methods:Microspheres and nanospheres (3500 nm and 700 nm) were prepared from three types of PLGA polymers (non-PEGylated and PEGylation percents of 9% and 15%). These particles were prepared by solvent evaporation method. All particles were labeled with FITC-Albumin. Interaction of particles with J744.A.1 mouse macrophage cells, was evaluated in the absence or presence of 7% of the serum by flowcytometry method. Results: The study revealed more phagocytosis of nanospheres. In the presence of the serum, PEGylated particles were phagocytosed less than non-PEGylated particles. For nanospheres, this difference was significant (P
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Journal title
volume 2 issue 4
pages 299- 304
publication date 2015-10-01
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